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CAPILLARYS® 3 DBS

A high-throughput Capillary Electrophoresis solution for newborn screening of hemoglobin disorders.

CAPILLARYS 3 DBS using the Capillary Electrophoresis technology

Key figures

  • 74

    tests/hour. High throughput to shorten turn-around time

  • 768

    sample loading capacity. High capacity to handle a fluctuating daily workload and reduce hands-on time

  • 5

    models of automated punchers compatible with our solution and used in newborn screening laboratories to ensure full traceability

  • 10

    working days of use for on-board Quality Control in daily operation

About CAPILLARYS 3 DBS

Capillary Electrophoresis (CE) is a well‑established technology for screening hemoglobin disorders and is recognized for delivering high‑quality, reliable results.

Sebia’s CAPILLARYS 3 DBS represents the latest generation of instruments dedicated to newborn hemoglobin screening, providing a streamlined workflow and outstanding analytical performance.

The CAPILLARYS 3 DBS is a fully automated Capillary Electrophoresis instrument that uses 12 parallel capillaries to perform multiple hands‑free electrophoretic separations simultaneously at high throughput.

The CAPILLARYS 3 DBS allows direct analysis of samples from microplate wells and delivers fully automated electrophoretic separation—from dried blood spots on filter paper (Guthrie cards) through the final electrophoretic profile. The system manages the entire workflow, including sample identification, dilution, incubation, capillary washing, sample injection into capillaries, migration, protein detection, results processing, and data transfer to the computer interface.

This instrument offers a compelling alternative to commonly used technologies such as IEF (IsoElectric Focusing) and HPLC for laboratories involved in newborn hemoglobin screening. It combines full sample traceability, high‑quality analytical results, and high throughput, while significantly reducing hands‑on time.

View of the inside of a CAPILLARYS 3 DBS

Key Benefits

The CAPILLARYS 3 DBS instrument is designed to address the evolving needs of modern laboratories, offering a comprehensive solution with valuable benefits.

  • High Throughput

    Up to 74 samples per hour, enabling newborn screening laboratories to handle their fluctuating workload and quickly transmit results to pathologists and clinicians.

  • High Autonomy

    Up to eight full 96‑well microplates can be processed in a single run without requiring any reagent refill. This substantially reduces hands‑on time and allows laboratory staff to focus on higher‑priority tasks.

  • Automatic Reagent Control

    RFID tags on all reagents and on the embedded Hb AF Control enable smooth, efficient reagent management and reduce the need for user intervention.

  • Full Traceability

    End-to-end traceability is maintained from sample punch to final result, eliminating manual transcription steps and reducing the risk of sample identification errors.

Pathologies associées

Technologies utilisées

Featured test for CAPILLARYS 3 DBS

Main Characteristics

Test menu

  • Hb Neonat technique

Sample type: dried blood spot (standard punch size of 3.2mm)

Performances

With 12 capillaries in parallel, the CAPILLARYS 3 DBS can process a large number of samples and can analyse up to eight 96-well microplates without reagent refill.

* Throughput (tests/hour) **

CAPI 3 NEONAT Hb 74

  • Using PHORESIS Software version 10.50

Reagents and Consumables

  • Flexible positions for reagents allow for the optimization of on-board reagent management
  • RFID identification for all reagents (reagent type, lot number, expiration date, volume) allows comprehensive traceability throughout workflow
  • RFID identification for Hb AF control (lot number, expiration date, date of first use, count of tests performed, and remaining tests) ensures full traceability and monitoring of the migration control’s use

Ergonomics

  • Embedded user interface with a touch screen
  • Automatic start-up and shutdown with daily scheduling options
  • Visual alarms (with instrument notifications)
  • A dedicated workstation operates the instrument and manages results

Instrument details

  • Uses barcoded microplates, included with the CAPI 3 NEONAT Hb reagent kit, with additional microplates available separately.
  • Direct sampling from dried blood spots (DBS) eluted from Guthrie filter paper
  • Validated with automated puncher systems, including Revvity™ (formerly PerkinElmer™) puncher instruments (Panthera 9 and DBS Puncher models) and BSD Robotics punchers
  • Full sample traceability from sample card ID up to results, via barcoded microplates
  • CAPILLARYS 3 DBS – P/N: 1244

Knowledge & Science

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Instruments related to CAPILLARYS 3 DBS

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