Vasculitis

Vasculitis and Beyond: A Broad Portfolio.

Vasculitis refer to a group of autoimmune diseases characterized by inflammation of small- to medium-sized blood vessels, often associated with anti-neutrophil cytoplasmic antibodies (ANCAs). This inflammation can lead to vessel damage, reduced blood flow, and tissue injury in multiple organs.ANCA-associated vasculitides primarily affect organs such as the kidneys, lungs, skin, and nervous system.Beyond vasculitis, the presence of ANCA has also been observed in other autoimmune and inflammatory conditions. These include disorders of the gastrointestinal tract, such as chronic inflammatory bowel diseases.Because of this broad clinical spectrum, ANCA testing plays an important role in differential diagnosis.