Evaluation of a semi-automated von Willebrand factor multimer assay
The diagnosis of von Willebrand disease requires multiple testing and includes the assessment of vWF multimer distribution.
vWF multimer analysis is labor intensive, non standardized and limited to specialized laboratories.
This article performed in two European centers, compared existing in-house multimer assays to Hydragel VW multimer assay in individuals with and without von Willebrand Disease.
As Hydragel VW multimer densitometry improved the diagnosis of VWD, the authors suggest its use as an initial screen of vWF multimers in a VWD diagnostic algorithm in conjunction with traditional multimer analysis.
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