Multiplex immunoassays
One sample. One well. Multiple assays. Improved efficiency.
Multiplex immunoassays are a cutting-edge technology combining the principles of fluorescence immunoassay (FIA) with the advantages of microarrays to enable simultaneous detection and quantification of multiple target analytes in a single sample.
In the context of autoimmune and infectious diseases, this technology refers to the simultaneous detection and measurement of multiple analytes such as auto-antibodies and antigens.
About Multiplex immunoassays
Microsphere-based fluorescent assays have been developped with the AtheNA Multi-Lyte® Test analyzer, built by Luminex® Corporation on the Luminex® 100/200™ System using xMAP® Technology.
This system uses polystyrene microspheres labelled internally with different ratios of two different fluorochrome (one red and one infrared) to provide a unique spectral signature. Each fluorochrome can have any of the 10 possible levels of fluorescence intensity, thereby creating a family of 100 spectrally addressed bead sets. The antigens corresponding to autoantibodies are bound to the microspheres. Each of the 100 microbeads that can be differentiated by their fluorescence carries a specific immobilized antigen for a single autoantibody.
At the same time, a green laser excites the external reporter fluorescence to quantify the specific reaction related to each autoantibody.
Pathologies available on Multiplex immunoassays
Our Instrument using Multiplex immunoassays Technology
One sample. One well. Multiple assays.
Knowledge & Science
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