Understand CDT-IFCC as an alcohol biomarker
Learn why CDT-IFCC is considered a highly specific marker for identifying chronic excessive alcohol consumption and how it compares with traditional biomarkers.
The importance of CDT-IFCC, marker of chronic alcohol excessive consumption
This webinar is presented in English.
Abstract
The presentation comprises of a brief introduction regarding the effects of excessive alcohol consumption, its impact globally and the timely apparition of serum CDT.
Serum total CDT was an improvement over traditional markers but had its pitfalls and limitations, until its path towards standardisation through the IFCC CDT Working group manifested and its evolution to CDT-IFCC.
Upon its recognition to being a very specific marker for chronic excessive alcohol consumption, CDT-IFCC is a valuable marker in both clinical (for example, primary care, psychiatry, lifestyle drinking, antenatal first trimester and emergency departments) and forensic settings (for example, driver licensing, aviation, locomotion, and maritime).
Capillary electrophoresis is the commercial alternative separation technique, which aims to mirror the IFCC approved standard reference HPLC procedure.
There is a great need to raise awareness and educate the importance of CDT-IFCC which is currently the only IFCC approved alcohol marker compared to other upcoming markers and they tend to be associated with short term drinking. CDT-IFCC has a half life of approximately two weeks and makes it an excellent retrospective marker.
The high specificity of CDT-IFCC in the assessment of chronic excessive consumption over traditional markers, its successful standardisation, its uses in both clinical and forensic settings can only indicate that it is ‘time for change’, with inclusive use of the marker by diagnostic service centres and increasing requests by their clients. Collaboration by diagnostic laboratories, local authorities, psychiatrists, primary cares, and CDT manufacturers would be a good approach to promote demand and uptake for CDT-IFCC.
What will you learn?
Explore the standardization journey of CDT testing
Discover the evolution from serum total CDT to CDT-IFCC through IFCC standardization efforts and the role of capillary electrophoresis in routine laboratory testing.
Recognize clinical and forensic applications of CDT-IFCC
Examine how CDT-IFCC supports decision-making in healthcare settings and forensic fields such as driver licensing, aviation, and occupational health monitoring.
The toxic effects of alcohol vary considerably from person to person
About Jean Deenmamode
Jean Deenmamode is Chair of the IFCC Working Group on Carbohydrate-Deficient Transferrin (WG-CDT). He is internationally recognized for his work on the standardization and clinical application of CDT-IFCC as a specific biomarker of chronic excessive alcohol consumption. Through his involvement with the IFCC, he supports the global harmonization of CDT testing and promotes its use in both clinical and forensic settings, including primary care, psychiatry, occupational health, and driver licensing programs.
Test associated with this resource
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