Understanding the Role of von Willebrand Factor (vWF)
Learn how vWF contributes to primary haemostasis and why its largest molecular weight multimers are critical for normal clot formation.
The contribution of multimer analysis in the diagnosis of von Willebrand disease
This webinar is presented in English.
Abstract
Von Willebrand factor (vWF) is a large multimeric protein that plays an important role in primary Haemostasis. vWF circulates as a series of oligomers comprising different sized subunits. It is the largest molecular weight subunits that are important for primary Haemostasis.
A reduction or dysfunction of vWF causes the Haemorrhagic disorder von Willebrand disease (vWD). VWD is the commonest bleeding disorder in humans with symptoms including bruising, epistaxis, menorrhagia and gasterointestinal or genitourinary bleeding. VWD is classified in to 3 types and several subtypes according to results determined by panel of laboratory assays.
Analysis of the multimer structure is necessary for subtyping vWD. Traditional multimer analysis methods are time consuming and laborious.
Sebia offer a semi-quantitive rapid multimer screening assay, HYDRASYS 5, with a one day turnaround time for results. This presentation will discuss the laboratory diagnosis of VWD and the use of the HYDRASYS 5 in the subtyping of vWD.
What will you learn?
Recognizing von Willebrand Disease (vWD)
Explore the causes, clinical manifestations and classification of vWD, the most common inherited bleeding disorder.
The Importance of Multimer Analysis in vWD Subtyping
Understand why evaluating the multimer structure of vWF is essential for accurately distinguishing between different types and subtypes of vWD.
Challenges of Traditional Multimer Testing
Discover the limitations of conventional multimer analysis methods, including their complexity, labour-intensive workflows and extended turnaround times.
Using HYDRASYS 5 for Rapid vWD Classification
Examine how the Sebia HYDRASYS 5 assay enables rapid, semi-quantitative multimer screening and supports efficient laboratory diagnosis and subtyping of vWD.
Multimer visualisation is necessary for VWD sub-typing
About Dr. Annette Bowyer
Dr. Annette Bowyer is the Lead Biomedical Scientist for Hemophilia Assays at the Sheffield Haemophilia and Thrombosis Centre, a facility recognized by the World Federation of Hemophilia (WFH) as an International Hemophilia Training Center.
She is actively involved in the advancement of haemostasis and thrombosis testing and serves on several scientific committees, including those of the World Federation of Hemophilia (WFH) and the International Society on Thrombosis and Haemostasis (ISTH).
Test associated with this resource
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