APS Testing Beyond the Criteria: The Value of Criteria and Non-Criteria aPL
Understanding the contribution of broader aPL testing to APS diagnosis and clinical evaluation.
- Antiphospholipid syndrome (APS) is a systemic autoimmune disorder associated with significant thrombotic and obstetric complications, making accurate serological assessment essential for appropriate patient management.
- Standard APS testing is based on the established criteria antibodies—anticardiolipin (aCL), anti-β2 glycoprotein I (aβ2GPI), and lupus anticoagulant (LA)—which form the foundation of current classification criteria.
- Going beyond the criteria may broaden clinical coverage: considering non-criteria antiphospholipid antibodies in selected patients, particularly in obstetric settings, may provide additional serological insights when clinical suspicion persists despite negative or inconclusive standard testing.
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