HEp-2 cells: a reliable tool for antinuclear antibodies screening
The whitepaper outlines the use of the Indirect Immunofluorescence (IFA) technique on HEp-2 cells as the gold standard for antinuclear antibodies (ANA) screening.
- Connective tissue diseases (CTD) are a group of disorders characterized by inflammation and autoimmune reactions that affect multiple organ systems
- The diagnosis of CTD uses IFA (Immunofluorescence Assays) for the determination of antinulcear antibodies (ANA), using human epithelial tumor cells (HEp-2), a stabilized cell line of human larynx carcinoma, known for its high sensitivity and specificity
- Having reliable solutions and high-quality HEp-2 cells are essential to proceed with clear identifications of ANA, making the diagnosis of CTD tempestive
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