Excellent separation
Capillary electrophoresis (CE) delivers clear and precise separation of hemoglobin fractions, supporting accurate HbA1c measurement and confidence in patient results.
About HbA1c
Worldwide, 589 million adults are living with diabetes, and nearly half remain undiagnosed. Glycated hemoglobin (HbA1c) is a cornerstone marker for both diagnosing diabetes and monitoring long‑term glycemic control, as it reflects the average blood glucose level over the previous three months.
More than 20 years ago, the WHO endorsed HbA1c as a diagnostic tool, establishing a threshold of 6.5% (48 mmol/mol).
Today, HbA1c testing remains essential for identifying diabetes and assessing disease progression in diagnosed patients.
Leveraging its extensive expertise in capillary electrophoresis, Sebia has optimized this high‑resolution technology for HbA1c analysis. This advanced method provides laboratories and clinicians with accurate, reliable, and clinically meaningful results, supporting improved patient care and long‑term disease management.
Pathologies associées
Technologies utilisées
Key benefits
High‑resolution solution ensuring high‑quality results for all patients.
Limited and visible analytical interferences
Capillary electrophoresis (CE) supports accurate HbA1c quantification in the presence of common analytical interferences, including labile A1c, carbamylated hemoglobin, Hb F, Hb S, Hb C, Hb D, and Hb E. Clear visual separation of hemoglobin fractions helps minimize potential interferences and provides visibility when they are present, supporting reliable result interpretation. The method also enables the incidental detection of common hemoglobin disorders such as sickle cell disease and β-thalassemia.
Meaningful results
Aligned with the IFCC reference method (HbA1c/(HbA1c+Hb A0)), capillary electrophoresis (CE) delivers accurate and reliable HbA1c results. Unlike some methods, Sebia CE does not generate erroneous HbA1c results in samples containing homozygous hemoglobin variants or in patients lacking HbA, providing greater confidence in reported results.
Adapted to each laboratory
With Sebia’s broad portfolio of capillary electrophoresis instruments, laboratories can select the platform that best matches their workflow—from compact standalone benchtop systems to fully integrated workcell configurations
Main characteristics
Test principle
HbA1c is formed by the irreversible glycation of hemoglobin A at the N-terminal valine of the β-globin chains.
Its concentration reflects average blood glucose exposure over the previous two to three months, making it a key marker for assessing long-term glycemic control.
HbA1c measurement is used:
-
Monitor diabetes control and evaluate treatment effectiveness.
-
Aid in the diagnosis of diabetes mellitus.
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Identify individuals at increased risk of developing diabetes.
Sample type
- Whole blood samples are used and analysed directly on Capillary instruments.
- The Sebia CAPILLARY BLOOD SAMPLE KIT can be used on Capillary instrument and is an interesting alternative to venous blood sampling for HbA1c measurement.
Performances
| HbA1c | Throughput (tests/hour)* |
|
8 |
|
42 |
|
63 |
|
185 |
No interference from common hemoglobin variants, or Hb F or carbamylated hemoglobin. Factors that Interfere with HbA1c Test Results
*Firmware-dependent; contact your local Sebia representative for current information.
**Maximum Capacity or MC designation refers to Tube Loader CAPILLARYS 3 - P/N: 1249 and Rack Conveyor CAPILLARYS 3 - P/N: 1250 associated with CAPILLARYS 3 TERA - P/N: 1246.
Product details
Each Sebia capillary instrument has a dedicated reagent kit to perform HbA1c analysis.
- CAPI 3 Hb A1c – P/N: 2515
- MINICAP Hb A1c – P/N: 2215
Knowledge & Science
HbA1c test can be performed on the following instruments
The compact and affordable automation of Capillary Electrophoresis.
Evolution makes the difference.
A concentrate of Sebia’s expertise in a high throughput instrument.
Capillary Electrophoresis solution to meet your high capacity needs.
Cette section contient des informations destinées à une large diffusion et peut donc comporter des détails sur des produits ou des informations qui ne sont pas disponibles ou valables dans votre pays. Veuillez contacter votre représentant Sebia local. Informations destinées aux professionnels de santé. Lisez attentivement les instructions figurant dans les notices des réactifs et les manuels d'utilisation des instruments.