HbA1c
- Capillary Electrophoresis
- Diabetes
Effects of hemoglobin C, D, E and S traits on measurements of hemoglobin A1c by twelve methods
Hemoglobin C, D Punjab, E or S trait can interfere with hemoglobin A1c (HbA1c) results depending on the method of analysis used. Therefore, it is important to know the limitations of the method used for HbA1c determination.
Hemoglobin A1c (HbA1c) is widely used for diabetes monitoring and diagnosis. As HbA1c results play a key role in clinical decision-making, analytical accuracy is essential to ensure appropriate patient management.
Hemoglobin variants can interfere with HbA1c measurements obtained with some assay methods. Common variants such as Hb S, Hb C, Hb E and Hb D-Punjab may lead to falsely elevated or falsely decreased HbA1c results. Clinically significant interference can result in inappropriate treatment decisions, including over-treatment with an increased risk of hypoglycemia or under-treatment associated with prolonged hyperglycemia and diabetes-related complications. In addition, inaccurate HbA1c results may impact the diagnosis of diabetes.
Hemoglobin variants are not uncommon and may be encountered in routine laboratory practice, particularly in regions with ethnically diverse populations. It is therefore important for laboratories to understand the susceptibility of HbA1c methods to variant interference and to select methods that have been demonstrated to provide accurate results in the presence of common hemoglobin variants. In this study, several methods, including capillary electrophoresis (CE) systems, showed no clinically significant interference from Hb S, Hb C, Hb E or Hb D-Punjab traits.
Test associated with this resource
Related instruments
The compact and affordable automation of Capillary Electrophoresis.
Evolution makes the difference.
A concentrate of Sebia’s expertise in a high throughput instrument.
Capillary Electrophoresis solution to meet your high capacity needs.
Discover more resources on Diabetes
Comprehensive data analysis and interpretation software for Sebia assays on electrophoresis instruments.
This section contains information intended for wide distribution and may therefore contain product details or information that is not available or valid in your country. Please contact your local Sebia representative. Information intended for healthcare professionals. Carefully read the instructions in the reagent package inserts and instrument manuals.